Deputies responded to a house on Alexander Acres in Mooresville and found a woman with life-threatening injuries.
She was rushed to the hospital, where she later died.
Warrants have been issued for Michael Frye, age 55.
Frye is believed to be driving a silver 2004 Toyota RAV4 with North Carolina license plate ECJ-6391.
If you see the vehicle or Frye, contact the Iredell County Sheriffs Office.